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Look, witty text!
Well, as I said, I only have trouble because I can't predict where and how Serris is going to pop up onto and fly across the screen.

That top-right ladder thing sounds easy enough, although I figure I'm best off just taking a moment to learn what kind of pattern he runs on.
well... i'm not sure you'd class it as a boss but i think the final SA-X chase is the hardest. the one where you gotta rol all over place and go backwards and forwards, when you go back to sector 2 to get rid of the weeds...

if you don't class that as a boss then i think the hardest boss is either:

Annoying Plant thing in Sector 2 (TRO) or the Final SA-X fight!
(not the one next to your ship)
zazabi the hardest boss?

i guess there's a first time for everything ...
soaking through
Uhm, couldn't it be Nettori?
soaking through
I'd assume it is, seeing as Zazabi doesn't actually look like a plant.  Plus he's not actually hard, and Nettori is.
Shifty Leader
That M2k2 guy
technically, nettori isn't all that hard, it's just the spores that get ya.
Actually, first time I played fusion the part where the wall shoots plasma beams killed me.
That's Nettori.
Mister ...
Isn't it basically some X PLants abusing a Chozo Statue's power or something?
Yeah, it could be. With the chozo containing plasma right?
I died a lot of times against Nightmare because of it's "I'm-moving-everywhere-so-you-cannot-hit-me-unless-you-try" and "I'm-moving-everywhere-so-if-you-try-to-hit-me-you'll-get-hit"... I hate collision damage.
I can remember clearly myself losing whereas I didn't know there was a save station around, so I hate even more Nightmare... This is most subjective.