Quote from Cpadolf:
it should be very possible to beat it without savestates, it's easier then SM:I, the last deathtroid room would probably be the most trouble you'll get, but since you can save between every deathtroid room that should not be so hard after all.
Hmm, I have not played this after my first, so I cannot exactly remember how hard those deathtroids were, but it sounds pretty retarded to do the "Tourian" in multiple segments in which you go back and forth just to empty one room at a time. On the other hand, "lameness" (strategy?) is the key to savestateless performances.
How about MB and escape? If you have to do all at once, that might bring some challenge (or maybe not, cannot remember much about those).
Well, if anyone wants to do it, I am rooting for ya. I stand out of this one since I do not consider it worthy of my time. =)