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Meta Ridley... looks best, best fight, quite tough first time around (before you know what tactics to use and so on) and just plain cool.
Ok, samus might have a bit of a vendetta against me, but at least I give her a hell of a time fulfilling it.  :P

And what do you mean, she doesn't have any reason to come after me? In 1, 0, and super, she had to kill Ridley to get to MB. And in Prime, she just knows that there are space pirates on the planet, and that they have metroids and are doing genetic engineering (Fall of Zebes and Parasite queen scans). That seems like enough reason for me to investigate. And she doesn't even come after me, she heads to the impact crater when I attack.
One shall stand, one shall ball.
Meta-Ridley: he flies, shoots missiles, have a fire beam (or something like that), drops cluster bombs, and best of all... he's resurected every time he dies can't argue with that.  Besides all that he's my favorite boss or character in the Metroid series, and has the best music in  MP, and looks awesome.
METROID PRIME OWNZ ALL so i will be him or her or it  8)