A one item 1 boss run is impossible, also, because you need either bombs or ice beam to get into tourian. For now, completely forget how, but I'll know when I get home.
>_> Yes. The problem with only one boss is that you need someway to get access to Tourian (only way is crossing the bridge, but that's out with only one boss defeated). I have no idea how it would be done with bombs, but if someone's done it, it must be possible. -_-