This shows that skipping Annihilator could be done in a SW-assisted any% run; doing this is easily far faster than actually fighting Quadraxis, and also allows for an (AFAIK) faster route through Sanctuary:
Screw Attack > Obtain Energy > Return Energy and get Cobalt > Spider > Sky Temple key > Leave Sanctuary
I'm pretty sure that Annihilator is barely useful anywhere. I don't see any drawback to skipping it, but am I missing anything?
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